Oral Nano-Delivery Systems for Colon-Targeted Drug Delivery of Traditional Chinese Medicine in Ulcerative Colitis
نویسندگان
چکیده
Ulcerative colitis (UC) is a type of inflammatory bowel disease with high recurrence rate. In this regard, sulfasalazine and immunosuppressive medications are often used for an extended period in clinical practice, but their effectiveness limited, they prone to side effects. Modern research has shown that herbal active ingredients Traditional Chinese Medicine (TCM), such as polyphenols, alkaloids, quinones, terpenes, have promising impact on treating UC via multi-target mechanism low Poor water solubility bioavailability these agents the gastrointestinal tract most challenging issues delivering target tissues. Researchers created variety oral colon-targeted nano-systems TCM response above formulation issues, which significantly improve treatment by avoiding damage, prolonging intestinal retention, achieving controlled drug release at lesion site. order provide ideas oral-targeted from TCM, progress nano-system reviewed current study, well UC. Keywords: Medicine, Traditional, Colitis, Ulcerative, Nanoparticle Drug Delivery System.
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متن کاملPectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: In-vitro/in-vivo Evaluation in Induced Ulcerative Colitis in Rat
Abstract The main objective of this study was to prepare colon-specific pellets of budesonide using pectin as film coating. Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH o...
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ژورنال
عنوان ژورنال: Bionatura (Ibarra - Impresa)
سال: 2023
ISSN: ['1390-9347', '1390-9355']
DOI: https://doi.org/10.21931/rb/2023.08.02.17